Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epigenetic Alterations and Canonical Pathway Disruption in Papillary Thyroid Cancer: A Genome-wide Methylation Analysis.

Annals of surgical oncology - 1 Jul 2016

White Michael G, Nagar Sapna, Aschebrook-Kilfoy Briseis, Jasmine Farzana, Kibriya Muhammad G, Ahsan Habibul, Angelos Peter, Kaplan Edwin L, Grogan Raymon H

Abstract excerpt

BACKGROUND: Alterations in DNA methylation have been demonstrated in a variety of malignancies, including papillary thyroid cancer (PTC). The full extent of dysregulation in PTC and the downstream affected pathways remains unclear. Here we report a genome-wide analysis of PTC methylation, the dysregulation of various canonical pathways, and assess its potential as a diagnostic test. METHODS: A discovery set...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers, Tumor
Share to Carcinoma, Papillary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CpG Islands

Share to DNA Methylation

Share to Epigenomics

Share to Follow-Up Studies

Share to Survival Rate

Share to Thyroid Neoplasms

Source

Identifiers

PMID: 26979305
DOI: 10.1245/s10434-016-5185-4

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epigenetic Alterations and Canonical Pathway Disruption in Papillary Thyroid Cancer: A Genome-wide Methylation Analysis.PMID 26979305Read ↗

Genome-wide methylation patterns in papillary thyroid cancer are distinct based on histological subtype and tumor genotype.Semantic proximity Read ↗

Integrated data analysis reveals potential drivers and pathways disrupted by DNA methylation in papillary thyroid carcinomas.Semantic proximity Read ↗

Integrated genomic characterization of papillary thyroid carcinoma.Semantic proximity Read ↗

Somatic Mutation Profiling of Papillary Thyroid Carcinomas by Whole-exome Sequencing and Its Relationship with Clinical Characteristics.Semantic proximity Read ↗

Classification of Thyroid Tumors Based on DNA Methylation Patterns.Semantic proximity Read ↗

Differences in miRNA and mRNA Profile of Papillary Thyroid Cancer VariantsSemantic proximity Read ↗

Comprehensive DNA Methylation Profiling Identifies Novel Diagnostic Biomarkers for Thyroid Cancer.Semantic proximity Read ↗

DNA methylation patterns define subtypes of differentiated follicular cell-derived thyroid neoplasms: an unsupervised machine learning approachSemantic proximity Read ↗

Papillary Thyroid Carcinoma Variants are Characterized by Co-dysregulation of Immune and Cancer Associated GenesSemantic proximity Read ↗

Whole-exome sequencing and bioinformatic analyses revealed differences in gene mutation profiles in papillary thyroid cancer patients with and without benign thyroid goitre background.Semantic proximity Read ↗

Discovery and validation of PARP4 methylation in distinguishing thyroid cancer from benign nodule.Semantic proximity Read ↗

Comprehensive transcriptomic profiling reveals molecular characteristics and biomarkers associated with risk stratification in papillary thyroid carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.