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Article

Discovery and validation of PARP4 methylation in distinguishing thyroid cancer from benign nodule.

Journal of endocrinological investigation - 1 Apr 2026

Li Mengxia, Yin Yifei, Mao Yizhu, Li Junjie, Huang Haixia, Zhang Minmin, Li Hong, Jiang Chenxia, Yang Rongxi

Abstract excerpt

PURPOSE: Malignancy evaluation of thyroid nodules is an important and challenging issue in clinical practice. In this study, we intended to explore novel biomarkers for the differential diagnosis of malignant and benign thyroid nodules. METHODS: We performed whole-genome DNA methylation profiling by MethylationEPIC BeadChip and expression profiling by RNA-Sequencing, to identify differentially methylated and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Poly(ADP-ribose) Polymerases

Share to Proto-Oncogene Proteins B-raf

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Source

Identifiers

PMID: 41428003
DOI: 10.1007/s40618-025-02785-0

Genes

PARP4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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