Article
Whole-exome sequencing and bioinformatic analyses revealed differences in gene mutation profiles in papillary thyroid cancer patients with and without benign thyroid goitre background.
Frontiers in endocrinology - 1 Jan 2022
Eng Zing Hong, Abdullah Mardiaty Iryani, Ng Khoon Leong, Abdul Aziz Azlina, Arba'ie Nurul Hannis, Mat Rashid Nurullainy, Mat Junit Sarni
Abstract excerpt
Background: Papillary thyroid cancer (PTC) is the most common thyroid malignancy. Concurrent presence of cytomorphological benign thyroid goitre (BTG) and PTC lesion is often detected. Aberrant protein profiles were previously reported in patients with and without BTG cytomorphological background. This study aimed to evaluate gene mutation profiles to further understand the molecular mechanism underlying BTG, PTC...
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