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Article

Integrated data analysis reveals potential drivers and pathways disrupted by DNA methylation in papillary thyroid carcinomas.

Clinical epigenetics - 1 Jan 2017

Beltrami Caroline Moraes, Dos Reis Mariana Bisarro, Barros-Filho Mateus Camargo, Marchi Fabio Albuquerque, Kuasne Hellen, Pinto Clóvis Antônio Lopes, Ambatipudi Srikant, Herceg Zdenko, Kowalski Luiz Paulo, Rogatto Silvia Regina

Abstract excerpt

BACKGROUND: Papillary thyroid carcinoma (PTC) is a common endocrine neoplasm with a recent increase in incidence in many countries. Although PTC has been explored by gene expression and DNA methylation studies, the regulatory mechanisms of the methylation on the gene expression was poorly clarified. In this study, DNA methylation profile (Illumina HumanMethylation 450K) of 41 PTC paired with non-neoplastic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28469731
DOI: 10.1186/s13148-017-0346-2
PMCID: PMC5414166

Genes

BRAF
ERBB3
FGF1
FGFR2
GABRB2
HMGA2
RDH5

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