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Article

Integrated genomic characterization of papillary thyroid carcinoma.

Cell - 23 Oct 2014

Abstract excerpt

Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Here, we describe the genomic landscape of 496 PTCs. We observed a low frequency of somatic alterations (relative to other carcinomas) and extended the set of known PTC driver alterations to include EIF1AX, PPM1D, and CHEK2 and diverse gene fusions. These discoveries reduced the fraction of PTC cases with unknown oncogenic driver from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25417114
DOI: 10.1016/j.cell.2014.09.050
PMCID: PMC4243044

Genes

BRAF
CHEK2

Provenance

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