Article
Targeted disruption of sp7 and myostatin with CRISPR-Cas9 results in severe bone defects and more muscular cells in common carp.
Scientific reports - 15 Mar 2016
Zhong Zhaomin, Niu Pengfei, Wang Mingyong, Huang Guodong, Xu Shuhao, Sun Yi, Xu Xiaona, Hou Yi, Sun Xiaowen, Yan Yilin, Wang Han
Abstract excerpt
The common carp (Cyprinus carpio) as one of the most important aquaculture fishes produces over 3 million metric tones annually, approximately 10% the annual production of the all farmed freshwater fish worldwide. However, the tetraploidy genome and long generation-time of the common carp have made its breeding and genetic studies extremely difficult. Here, TALEN and CRISPR-Cas9, two versatile genome-editing...
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