Article

Crispant analysis in zebrafish as a tool for rapid functional screening of disease-causing genes for bone fragility

2024-06-28

Abstract excerpt

Heritable Fragile Bone Disorders (FBDs) encompass a spectrum of conditions, from widespread multifactorial to rare monogenic diseases, all characterized by an elevated risk of fractures. The process of validating causative genes and elucidating their pathogenic mechanisms remains a daunting and resource-intensive task. In this study, we evaluated the feasibility of a semi-high throughput zebrafish screening platfo...

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Literature Corpus work: ba04b658-6fac-5a0e-9f89-44b37ce27987
DOI: 10.1101/2024.06.27.601074

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