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Article

Inheritance of the epigenetic signature and reduced intermuscular bone phenotype acquired via DNA methylation editing of the runx2 b promoter in zebrafish.

Zoological research - 18 Sept 2026

Liang Fang, Wu Bi-Yu, Liu Jia-Yi, Wang Xue, Liang Min-Xing, Wang Chao-Yi, Zhang Jing-Yi, Wang Jun-Jie, Miao Yu-Tao, Mai Kang-Sen, Zhao Jun, Wang Xue-Geng

Abstract excerpt

The presence of intermuscular bones (IBs) can directly affect the economic value of aquaculture fish. Although genome editing can create IB-free fish by knocking out key IB-related genes, such as runx2b, the associated DNA sequence alterations raise food safety and health concerns, limiting its breeding applications. In this study, we used CRISPR/dCas9-mediated epigenome-editing technology targeting the runx2 b...

Read the complete abstract on PubMed

Topics

Animals
Zebrafish
DNA Methylation
Promoter Regions, Genetic
Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Core Binding Factor Alpha 1 Subunit

Gene Editing

Phenotype

Zebrafish Proteins

Epigenetic Memory

CRISPR-Cas Systems

Source

Identifiers

PMID: 42733042
DOI: 10.24272/j.issn.2095-8137.2025.494

Genes

F2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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