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A Role for P-Glycoprotein in Clearance of Alzheimer Amyloid ? -Peptide from the Brain

15 Apr 2016

Abstract excerpt

Most data indicates that Alzheimer's disease involves an accumulation of amyloid β - peptide (Aβ) in the CNS and that sporadic cases arise from a deficiency in Aβ clearance. Considerable attention has been given to mechanisms by which Aβ might be transported between the brain and blood, and evidence suggests that p-glycoprotein, also known as the multi-drug resistance (MDR) protein (product of the ABCB1 gene),...

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PMID: 26971931
DOI: 10.2174/1567205013666160314151012

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