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P-glycoprotein and Alzheimer’s Disease: Threats and Opportunities

23 Apr 2025

Abstract excerpt

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that affects more than 50 million people worldwide. One of the hallmark features of AD is the accumulation of amyloid β-peptide (Aβ) protein in the brain. P-glycoprotein (P-gp) is a membrane-bound protein expressed in various tissues, including the cerebrovascular endothelium. It plays a crucial role in the efflux of toxic substances, including...

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PMID: 40264334
DOI: 10.1080/17590914.2025.2495632

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