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Blood-Brain Barrier P-Glycoprotein Function in Neurodegenerative Disease

1 Sept 2011

Abstract excerpt

Protection of the brain is strengthened by active transport and ABC transporters. P-glycoprotein (P-gp) at the blood-brain barrier (BBB) functions as an active efflux pump by extruding a substrate from the brain, which is important for maintaining loco-regional homeostasis in the brain and protection against toxic compounds. Importantly, dysfunctional BBB P-gp transport is postulated as an important factor...

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PMID: 21831040
DOI: 10.2174/138161211797440122

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