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Article

ABCB1 genotype and CSF beta-amyloid in Alzheimer disease.

Journal of geriatric psychiatry and neurology - 1 Jun 2011

Kohen R, Shofer J B, Korvatska O, Petrie E C, Wang L Y, Schellenberg G D, Peskind E R, Wilkinson C W

Abstract excerpt

The ABCB1 gene, coding for the efflux transporter P-glycoprotein (PGP), is a candidate gene for Alzheimer disease (AD). P-glycoprotein is heavily expressed at the blood-brain barrier, where it mediates the efflux of β-amyloid (Aβ) from the brain. In this study, we investigated a possible association between 2 common ABCB1 polymorphisms, G2677T/A (Ala893Ser/Thr) and C3435T, AD, and cerebrospinal fluid (CSF) levels...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21478475
DOI: 10.1177/0891988711402325
PMCID: PMC3293495

Genes

ABCB1
PGP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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