Article
Increased efflux of amyloid-β peptides through the blood-brain barrier by muscarinic acetylcholine receptor inhibition reduces pathological phenotypes in mouse models of brain amyloidosis.
Journal of Alzheimer's disease : JAD - 1 Jan 2014
Paganetti Paolo, Antoniello Katia, Devraj Kavi, Toni Nicolas, Kieran Dairin, Madani Rime, Pihlgren Maria, Adolfsson Oskar, Froestl Wolfgang, Schrattenholz André, Liebner Stefan, Havas Daniel, Windisch Manfred, Cirrito John R, Pfeifer Andrea, Muhs Andreas
Abstract excerpt
The formation and accumulation of toxic amyloid-β peptides (Aβ) in the brain may drive the pathogenesis of Alzheimer's disease. Accordingly, disease-modifying therapies for Alzheimer's disease and related disorders could result from treatments regulating Aβ homeostasis. Examples are the inhibition of production, misfolding, and accumulation of Aβ or the enhancement of its clearance. Here we show that oral...
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