Article
Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aβ clearance in a mouse model of β-amyloidosis.
Proceedings of the National Academy of Sciences of the United States of America - 18 Sept 2012
Castellano Joseph M, Deane Rashid, Gottesdiener Andrew J, Verghese Philip B, Stewart Floy R, West Tim, Paoletti Andrew C, Kasper Tristan R, DeMattos Ronald B, Zlokovic Berislav V, Holtzman David M
Abstract excerpt
The apolipoprotein E (APOE)-ε4 allele is the strongest genetic risk factor for late-onset, sporadic Alzheimer's disease, likely increasing risk by altering amyloid-β (Aβ) accumulation. We recently demonstrated that the low-density lipoprotein receptor (LDLR) is a major apoE receptor in the brain that strongly regulates amyloid plaque deposition. In the current study, we sought to understand the mechanism by which...
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