Article
Deposition of Alzheimer's beta-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans.
Pharmacogenetics - 1 Oct 2002
Vogelgesang Silke, Cascorbi Ingolf, Schroeder Eike, Pahnke Jens, Kroemer Heyo K, Siegmund Werner, Kunert-Keil Christiane, Walker Lary C, Warzok Rolf W
Abstract excerpt
Deposition of the beta-amyloid peptide (Abeta) in the brain occurs during normal ageing and is substantially accelerated in patients with Alzheimer's disease. Since Abeta is continuously produced in the brain, it has been suggested that a clearance mechanism should exist to prevent its accumulation and subsequent aggregation. Until now, little attention has been paid to the possible role of P-glycoprotein (P-gp),...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.