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Article

Impaired αGDI Function in the X-Linked Intellectual Disability: The Impact on Astroglia Vesicle Dynamics.

Molecular neurobiology - 1 May 2017

Potokar Maja, Jorgačevski Jernej, Lacovich Valentina, Kreft Marko, Vardjan Nina, Bianchi Veronica, D'Adamo Patrizia, Zorec Robert

Abstract excerpt

X-linked non-syndromic intellectual disability (XLID) is a common mental disorder recognized by cognitive and behavioral deficits. Mutations in the brain-specific αGDI, shown to alter a subset of RAB GTPases redistribution in cells, are linked to XLID, likely via changes in vesicle traffic in neurons. Here, we show directly that isolated XLID mice astrocytes, devoid of pathologic tissue environment, exhibit...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 26971292
DOI: 10.1007/s12035-016-9834-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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