The adhesion GPCR ADGRV1 controls glutamate homeostasis in hippocampal astrocytes supporting neuron development: first insights into to pathophysiology of <i>ADGRV1</i> -associated epilepsy

Abstract excerpt

ADGRV1 is the largest member of adhesion G protein-coupled receptor (aGPCR) family. In the cell, aGPCRs have dual roles in cell adhesion and signal transduction. Mutations in ADGRV1 have been linked not only to Usher syndrome (USH), which causes deaf-blindness, but recently also to various forms of epilepsy. While the USH defects are attributed to the loss of fiber links between membranes formed by the extracellu...

Topics

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• 8-Bromo Cyclic Adenosine Monophosphate
• Alexander Disease
• Astrocytes
• Autophagy in Disease and Therapy
• Calcium signaling and nucleotide metabolism
• Cell Adhesion Molecules Research
• Cellular transport and secretion
• Receptor Mechanisms and Signaling

Identifiers and source

Literature Corpus work

1e16abc4-f203-5a94-82e7-3cf24af514c1

DOI

10.1101/2024.04.25.591120