Article

Defective neuritogenesis in <i>Abcd1/2</i> deficient rat neurons due to intrinsic and astrocyte-dependent mechanisms

2022-10-03

Abstract excerpt

<h4>ABSTRACT</h4> X-linked adrenoleukodystrophy (X-ALD) is a rare neurometabolic and demyelinating disorder caused by loss of function mutations of the ABCD1 transporter that imports very-long-chain fatty acids (VLCFA) into the peroxisome for beta-oxidation. Impaired ABCD1 function results in VLCFA accumulation, which ultimately causes lethal forms of X-ALD in children (CCALD) and adults (CAMN). Because X-ALD is...

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Literature Corpus work: 8a5f68de-798b-5058-887b-8d5998281ed9
DOI: 10.1101/2022.09.30.510337

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