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Article

Nitrilase 1 modulates lung tumor progression in vitro and in vivo.

Oncotarget - 19 Apr 2016

Wang Yong Antican, Sun Yunguang, Le Blanc Justin M, Solomides Charalambos, Zhan Tingting, Lu Bo

Abstract excerpt

Uncovering novel growth modulators for non-small cell lung cancer (NSCLC) may lead to new therapies for these patients. Previous studies suggest Nit1 suppresses chemically induced carcinogenesis of the foregut in a mouse model. In this study we aimed to determine the role of Nit1 in a transgenic mouse lung cancer model driven by a G12D Kras mutation. Nit1 knockout mice (Nit1-/-) were crossed with KrasG12D/+ mice...

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Identifiers

PMID: 26967383
DOI: 10.18632/oncotarget.7820
PMCID: PMC5008292

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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