Article
NeuroD1 mediates nicotine-induced migration and invasion via regulation of the nicotinic acetylcholine receptor subunits in a subset of neural and neuroendocrine carcinomas.
Molecular biology of the cell - 1 Jun 2014
Osborne Jihan K, Guerra Marcy L, Gonzales Joshua X, McMillan Elizabeth A, Minna John D, Cobb Melanie H
Abstract excerpt
Cigarette smoking is a major risk factor for acquisition of small cell lung cancer (SCLC). A role has been demonstrated for the basic helix-loop-helix transcription factor NeuroD1 in the pathogenesis of neural and neuroendocrine lung cancer, including SCLC. In the present study we investigate the possible function of NeuroD1 in established tumors, as well as actions early on in pathogenesis, in response to...
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