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Article

A Gain-Of-Function Mutation in the Plcg2 Gene Protects Mice from Helicobacter felis-Induced Gastric MALT Lymphoma.

PloS one - 1 Jan 2016

Gossmann Jennifer, Stolte Manfred, Lohoff Michael, Yu Philipp, Moll Roland, Finkernagel Florian, Garn Holger, Brendel Cornelia, Bittner Alwina, Neubauer Andreas, Huynh Minh Q

Abstract excerpt

Gastric mucosa-associated lymphoid tissue (MALT) lymphomas develop from a chronic Helicobacter infection. Phospholipase C gamma 2 (PLCG2) is important for B-cell survival and proliferation. We used BALB/c mice with a gain-of-function mutation in the Plcg2 gene (Ali5) to analyze its role in the development of gastric MALT lymphoma. Heterozygous BALB/c Plcg2Ali5/+ and wildtype (WT) mice were infected with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin G

Share to Lymphoma, B-Cell, Marginal Zone

Share to Mice, Inbred BALB C

Share to Phospholipase C gamma

Share to Stomach Neoplasms

Share to T-Lymphocytes, Regulatory

Source

Open in PubMed Open full text

Identifiers

PMID: 26966907
DOI: 10.1371/journal.pone.0150411
PMCID: PMC4788355

Genes

PLCG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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