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Article

T-bet knockout prevents Helicobacter felis-induced gastric cancer.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2009

Stoicov Calin, Fan Xueli, Liu Jian Hua, Bowen Glennice, Whary Mark, Kurt-Jones Evelyn, Houghton JeanMarie

Abstract excerpt

Helicobacter infection is the primary risk factor for gastric cancer, with the cytokine environment within the gastric mucosa the strongest predictor of disease risk. Elevated TNF-alpha, IL-1beta, and low IL-10 are associated with the highest risk. In this study, we used C57BL/6 mice to identify T-bet as a central regulator of the cytokine environment during Helicobacter felis infection. We infected male and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19535625
DOI: 10.4049/jimmunol.0900511
PMCID: PMC3966469

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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