Article

Inhibition of the tuft cell/ILC2 axis reduces gastric tumor development in mice

2022-02-18

Abstract excerpt

Although gastric cancer is a leading cause of cancer-related deaths, systemic treatment strategies remain scarce. Here we explore a metabolite-triggered circuit between epithelial tuft cells and innate lymphoid type 2 cells (ILC2) that is evolutionarily optimized for intestinal remodeling in response to helminth infection. We demonstrate that tuft cell-derived interleukin 25 (IL25) acts as an alarmin on ILC2s to i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d1158e06-3ff7-5a91-a129-b2b5927cc29d
DOI: 10.1101/2022.02.16.480779

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Inhibition of the tuft cell/ILC2 axis reduces gastric tumor development in miceDOI 10.1101/2022.02.16.480779Read

A tuft cell - ILC2 signaling circuit provides therapeutic targets to inhibit gastric metaplasia and tumor developmentSemantic proximity Read

Circulating inflammatory ILC2s as a biomarker of gastric cancer progressionSemantic proximity Read

An innate IL-25-ILC2-MDSC axis creates a cancer-permissive microenvironment for Apc mutation-driven intestinal tumorigenesis.Semantic proximity Read

Initiation of inflammatory tumorigenesis by CTLA4 insufficiency due to type 2 cytokinesSemantic proximity Read

IL13 Acts Directly on Gastric Epithelial Cells to Promote Metaplasia Development During Chronic GastritisSemantic proximity Read

Precancerous pathways to gastric cancer: a review of experimental animal models recapitulating the correa cascadeSemantic proximity Read

BATF acts as an essential regulator of IL-25–responsive migratory ILC2 cell fate and functionSemantic proximity Read

<i>Candida albicans</i> reprograms host inosine metabolism to drive immunosuppressive macrophage polarization and gastric cancer carcinogenesisSemantic proximity Read

Autophagy-driven modulation of stem cell dynamics in Helicobacter pylori -induced gastric diseases in miceSemantic proximity Read

ILC2 Activation by Protozoan Commensal MicrobesSemantic proximity Read

Stomach microbiota, Helicobacter pylori, and group 2 innate lymphoid cellsSemantic proximity Read

Single-cell profiling uncovers a <i>Muc4</i> -expressing metaplastic gastric cell type sustained by <i>Helicobacter pylori</i> -specific inflammationSemantic proximity Read