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Article

Integrated molecular mechanism directing nucleosome reorganization by human FACT.

Genes & development - 15 Mar 2016

Tsunaka Yasuo, Fujiwara Yoshie, Oyama Takuji, Hirose Susumu, Morikawa Kosuke

Abstract excerpt

Facilitates chromatin transcription (FACT) plays essential roles in chromatin remodeling during DNA transcription, replication, and repair. Our structural and biochemical studies of human FACT-histone interactions present precise views of nucleosome reorganization, conducted by the FACT-SPT16 (suppressor of Ty 16) Mid domain and its adjacent acidic AID segment. AID accesses the H2B N-terminal basic region exposed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26966247
DOI: 10.1101/gad.274183.115
PMCID: PMC4803053

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