Article
Assignment of Functional Relevance to Genes at Type 2 Diabetes-Associated Loci Through Investigation of β-Cell Mass Deficits.
Molecular endocrinology (Baltimore, Md.) - 1 Apr 2016
O'Hare Elizabeth A, Yerges-Armstrong Laura M, Perry James A, Shuldiner Alan R, Zaghloul Norann A
Abstract excerpt
Type 2 diabetes (T2D) has been associated with a large number of genomic loci, many of which encompass multiple genes without a definitive causal gene. This complexity has hindered efforts to clearly identify functional candidate genes and interpret their role in mediating susceptibility to disease. Here we examined the relevance of individual genes found at T2D-associated loci by assessing their potential...
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