Natural history of β-cell adaptation and failure in type 2 diabetes.

doi:10.1016/j.mam.2014.12.002

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Article

Natural history of β-cell adaptation and failure in type 2 diabetes.

Molecular aspects of medicine - 1 Apr 2015

Alejandro Emilyn U, Gregg Brigid, Blandino-Rosano Manuel, Cras-Méneur Corentin, Bernal-Mizrachi Ernesto

Abstract excerpt

Type 2 diabetes mellitus (T2D) is a complex disease characterized by β-cell failure in the setting of insulin resistance. The current evidence suggests that genetic predisposition, and environmental factors can impair the capacity of the β-cells to respond to insulin resistance and ultimately lead to their failure. However, genetic studies have demonstrated that known variants account for less than 10% of the...

Topics

Animals
Cell Differentiation
Diabetes Mellitus, Type 2
Endoplasmic Reticulum Stress
Female
Genetic Predisposition to Disease
Humans
Insulin Resistance
Insulin-Secreting Cells
Oxidative Stress
Pancreas
Pregnancy
Rodentia

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Identifiers

PMID: 25542976
DOI: 10.1016/j.mam.2014.12.002
PMCID: PMC4404183

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