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Article

Characterization of the Adeno-Associated Virus 1 and 6 Sialic Acid Binding Site.

Journal of virology - 1 Jun 2016

Huang Lin-Ya, Patel Ami, Ng Robert, Miller Edward Blake, Halder Sujata, McKenna Robert, Asokan Aravind, Agbandje-McKenna Mavis

Abstract excerpt

UNLABELLED: The adeno-associated viruses (AAVs), which are being developed as gene delivery vectors, display differential cell surface glycan binding and subsequent tissue tropisms. For AAV serotype 1 (AAV1), the first viral vector approved as a gene therapy treatment, and its closely related AAV6, sialic acid (SIA) serves as their primary cellular surface receptor. Toward characterizing the SIA binding site(s),...

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Identifiers

PMID: 26962225
DOI: 10.1128/JVI.00161-16
PMCID: PMC4934739

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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