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Article

Single amino acid changes can influence titer, heparin binding, and tissue tropism in different adeno-associated virus serotypes.

Journal of virology - 1 Nov 2006

Wu Zhijian, Asokan Aravind, Grieger Joshua C, Govindasamy Lakshmanan, Agbandje-McKenna Mavis, Samulski R Jude

Abstract excerpt

Despite the high degree of sequence homology between adeno-associated virus (AAV) serotype 1 and 6 capsids (99.2%), these viruses have different liver transduction profiles when tested as vectors. Examination of the six amino acid residues that differ between AAV1 and AAV6 revealed that a lysine-to-glutamate change (K531E) suppresses the heparin binding ability of AAV6. In addition, the same mutation in AAV6...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16943302
DOI: 10.1128/JVI.01288-06
PMCID: PMC1642158

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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