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Article

Axl phosphorylates Elmo scaffold proteins to promote Rac activation and cell invasion.

Molecular and cellular biology - 1 Jan 2015

Abu-Thuraia Afnan, Gauthier Rosemarie, Chidiac Rony, Fukui Yoshinori, Screaton Robert A, Gratton Jean-Philippe, Côté Jean-François

Abstract excerpt

The receptor tyrosine kinase Axl contributes to cell migration and invasion. Expression of Axl correlates with metastatic progression in cancer patients, yet the specific signaling events promoting invasion downstream of Axl are poorly defined. Herein, we report Elmo scaffolds to be direct substrates and binding partners of Axl. Elmo proteins are established to interact with Dock family guanine nucleotide...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25332238
DOI: 10.1128/MCB.00764-14
PMCID: PMC4295393

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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