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Article

Dual Role of SnoN in Mammalian Tumorigenesis

13 Dec 2006

Abstract excerpt

SnoN is an important negative regulator of transforming growth factor beta signaling through its ability to interact with and repress the activity of Smad proteins. It was originally identified as an oncoprotein based on its ability to induce anchorage-independent growth in chicken embryo fibroblasts. However, the roles of SnoN in mammalian epithelial carcinogenesis have not been well defined. Here we show for...

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PMID: 17074815
DOI: 10.1128/mcb.01394-06

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