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Article

FMNL2 is a positive regulator of cell motility and metastasis in colorectal carcinoma

3 Feb 2011

Abstract excerpt

FMNL2 is a member of diaphanous-related formins which act as effectors of Rho family GTPases and control the actin-dependent processes such as cell motility or invasion. We previously found that FMNL2 overexpression in metastatic cell lines and tissues of colorectal carcinoma is associated with more aggressive tumour behaviour. Here we used gain-of-function and loss-of-function approaches to investigate the...

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PMID: 21506128
DOI: 10.1002/path.2871

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