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Article

Hsp72 (HSPA1A) Prevents Human Islet Amyloid Polypeptide Aggregation and Toxicity: A New Approach for Type 2 Diabetes Treatment.

PloS one - 1 Jan 2016

Rosas Paola C, Nagaraja Ganachari M, Kaur Punit, Panossian Alexander, Wickman Georg, Garcia L Rene, Al-Khamis Fahd A, Asea Alexzander A A

Abstract excerpt

Type 2 diabetes is a growing public health concern and accounts for approximately 90% of all the cases of diabetes. Besides insulin resistance, type 2 diabetes is characterized by a deficit in β-cell mass as a result of misfolded human islet amyloid polypeptide (h-IAPP) which forms toxic aggregates that destroy pancreatic β-cells. Heat shock proteins (HSP) play an important role in combating the unwanted...

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Identifiers

PMID: 26960140
DOI: 10.1371/journal.pone.0149409
PMCID: PMC4784952

Genes

IAPP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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