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Inhibition of Abeta Proteotoxicity by Paeoniflorin in Caenorhabditis elegans Through Regulation of Oxidative and Heat Shock Stress Responses

19 Oct 2017

Abstract excerpt

Alzheimer's disease (AD) is a common form of dementia and amyloid-β peptide (Aβ) aggregation is considered to be one of its main causes. Paeoniflorin has been previously shown to attenuate cognitive damage inflicted by exogenous Aβ protein. Using transgenic Caenorhabditis elegans models expressing human Aβ 1–42 , we demonstrate here that paeoniflorin can delay progressive paralysis caused by endogenous Aβ...

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PMID: 29048250
DOI: 10.1089/rej.2017.1966

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