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Article

Inhibition of chaperone-mediated autophagy prevents glucotoxicity in the Caenorhabditis elegans mev-1 mutant by activation of the proteasome.

Biochemical and biophysical research communications - 26 Feb 2017

Eisermann Dorothé Jenni, Wenzel Uwe, Fitzenberger Elena

Abstract excerpt

Chronic hyperglycemia is a hallmark of diabetes mellitus and the main cause of diabetes-associated complications. Increased intracellular glucose levels lead to damaged proteins and in consequence disturb cellular proteostasis. As an important contributor to the maintenance and restoration of proteostasis, autophagy mediates the lysosomal degradation of damaged proteins or entire cellular organelles. In the...

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PMID: 28089866
DOI: 10.1016/j.bbrc.2017.01.043

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