Article
Host-specific adaptation of HIV-1 subtype B in the Japanese population.
Journal of virology - 1 May 2014
Chikata Takayuki, Carlson Jonathan M, Tamura Yoshiko, Borghan Mohamed Ali, Naruto Takuya, Hashimoto Masao, Murakoshi Hayato, Le Anh Q, Mallal Simon, John Mina, Gatanaga Hiroyuki, Oka Shinichi, Brumme Zabrina L, Takiguchi Masafumi
Abstract excerpt
UNLABELLED: The extent to which HIV-1 clade B strains exhibit population-specific adaptations to host HLA alleles remains incompletely known, in part due to incomplete characterization of HLA-associated HIV-1 polymorphisms (HLA-APs) in different global populations. Moreover, it remains unknown to what extent the same HLA alleles may drive significantly different escape pathways across populations. As the Japanese...
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