Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Elevated linezolid resistance in clinical cfr-positive Staphylococcus aureus isolates is associated with co-occurring mutations in ribosomal protein L3.

Antimicrobial agents and chemotherapy - 1 Dec 2010

Locke Jeffrey B, Morales Gracia, Hilgers Mark, G C Kedar, Rahawi Shahad, José Picazo Juan, Shaw Karen Joy, Stein Jeffrey L

Abstract excerpt

Resistance to linezolid (LZD) occurs through mutations in 23S rRNA and ribosomal proteins L3 and L4 or through methylation of 23S rRNA by Cfr. Here we report novel L3 mutations, ΔSer145/His146Tyr and ΔMet169-Gly174, co-occurring with cfr in LZD-resistant Staphylococcus aureus isolates recovered from a hospital outbreak in Madrid, Spain. LZD MIC values (16, 32, or 64 μg/ml) correlated with the presence and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetamides
Share to Anti-Infective Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Bacterial

Share to Linezolid

Share to Methyltransferases

Share to Oxazolidinones

Share to Ribosomal Proteins

Share to Staphylococcus aureus

Source

Open in PubMed Open full text

Identifiers

PMID: 20837755
DOI: 10.1128/AAC.00714-10
PMCID: PMC2981277

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Elevated linezolid resistance in clinical cfr-positive Staphylococcus aureus isolates is associated with co-occurring mutations in ribosomal protein L3.PMID 20837755Read ↗

Resistance to linezolid in Staphylococcus spp. clinical isolates associated with ribosomal binding site modifications: novel mutation in domain V of 23S rRNA.Semantic proximity Read ↗

Resistance to linezolid in Staphylococcus aureus by mutation, modification, and acquisition of genes.Semantic proximity Read ↗

Combined Effect of the Cfr Methyltransferase and Ribosomal Protein L3 Mutations on Resistance to Ribosome-Targeting Antibiotics.Semantic proximity Read ↗

Detection of linezolid-resistant Staphylococcus aureus with 23S rRNA and novel L4 riboprotein mutations in a cystic fibrosis patient in Spain.Semantic proximity Read ↗

Novel ribosomal mutations in Staphylococcus aureus strains identified through selection with the oxazolidinones linezolid and torezolid (TR-700).Semantic proximity Read ↗

Mutations in ribosomal protein L3 are associated with oxazolidinone resistance in staphylococci of clinical origin.Semantic proximity Read ↗

Resistance to Linezolid Caused by Modifications at Its Binding Site on the RibosomeSemantic proximity Read ↗

Structure-activity relationships of diverse oxazolidinones for linezolid-resistant Staphylococcus aureus strains possessing the cfr methyltransferase gene or ribosomal mutations.Semantic proximity Read ↗

Mechanisms of linezolid resistance in staphylococci and enterococci isolated from two teaching hospitals in Shanghai, ChinaSemantic proximity Read ↗

The emerging problem of linezolid-resistant <i>Staphylococcus</i>Semantic proximity Read ↗

Mechanisms of Linezolid Resistance Among Clinical Staphylococcus spp. in Spain: Spread of Methicillin- and Linezolid-Resistant S. epidermidis ST2Semantic proximity Read ↗

Mutations within the rplD Gene of Linezolid-Nonsusceptible Streptococcus pneumoniae Strains Isolated in the United States.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.