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Article

A novel mechanism of streptomycin resistance in Yersinia pestis: Mutation in the rpsL gene.

PLoS neglected tropical diseases - 1 Apr 2021

Dai Ruixia, He Jian, Zha Xi, Wang Yiting, Zhang Xuefei, Gao He, Yang Xiaoyan, Li Juan, Xin Youquan, Wang Yumeng, Li Sheng, Jin Juan, Zhang Qi, Bai Jixiang, Peng Yao, Wu Hailian, Zhang Qingwen, Wei Baiqing, Xu Jianguo, Li Wei

Abstract excerpt

Streptomycin is considered to be one of the effective antibiotics for the treatment of plague. In order to investigate the streptomycin resistance of Y. pestis in China, we evaluated streptomycin susceptibility of 536 Y. pestis strains in China in vitro using the minimal inhibitory concentration (MIC) and screened streptomycin resistance-associated genes (strA and strB) by PCR method. A clinical Y. pestis isolate...

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Identifiers

PMID: 33886558
DOI: 10.1371/journal.pntd.0009324
PMCID: PMC8096067

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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