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Article

rplC T460C identified as a dominant mutation in linezolid-resistant Mycobacterium tuberculosis strains.

Antimicrobial agents and chemotherapy - 1 May 2012

Beckert Patrick, Hillemann Doris, Kohl Thomas A, Kalinowski Jörn, Richter Elvira, Niemann Stefan, Feuerriegel Silke

Abstract excerpt

The ribosomal L3 protein was identified as a novel target in linezolid (LZD)-resistant Mycobacterium tuberculosis strains. Next-generation sequencing confirmed rplC T460C as the sole mutation in an LZD-resistant M. tuberculosis H37Rv strain selected in vitro. Sequencing analysis revealed the rplC...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22371899
DOI: 10.1128/AAC.06227-11
PMCID: PMC3346602

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22371899-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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