Article
Structural basis for targeting the ribosomal protein S1 of Mycobacterium tuberculosis by pyrazinamide.
Molecular microbiology - 1 Mar 2015
Yang Juanjuan, Liu Yindi, Bi Jing, Cai Qixu, Liao Xinli, Li Wenqian, Guo Chenyun, Zhang Qian, Lin Tianwei, Zhao Yufen, Wang Honghai, Liu Jun, Zhang Xuelian, Lin Donghai
Abstract excerpt
Pyrazinamide (PZA) is a first-line drug for tuberculosis (TB) treatment and is responsible for shortening the duration of TB therapy. The mode of action of PZA remains elusive. RpsA, the ribosomal protein S1 of Mycobacterium tuberculosis (Mtb), was recently identified as a target of PZA based on its binding activity to pyrazinoic acid (POA), the active form of PZA. POA binding to RpsA led to the inhibition of...
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