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Article

Analysis of silent information regulator 1 (SIRT1) gene polymorphisms in antituberculosis- drug-induced hepatotoxicity in a prospective cohort study.

International journal of clinical pharmacology and therapeutics - 1 Oct 2016

Wang Yu, Yan Xiu-Ying, Wu Jing-Can, Ji Gui-Yi, Wu Shou-Quan, Huang Wei-Wei, Chen Guo, Sandford Andrew J, He Jian-Qing

Abstract excerpt

OBJECTIVE: Antituberculosisdrug-induced hepatotoxicity (ATDH) is a common and sometimes serious side effect related to tuberculosis (TB) treatment. A number of risk factors and host genetics contribute to the development of ATDH. However, genetic factors of ATDH remain to be identified. Silent Information Regulator 1 (SIRT1), an essential metabolism gene, was proved to be involved in ATDH in mice. The aim of this...

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Identifiers

PMID: 26952036
DOI: 10.5414/CP202506

Genes

SIRT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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