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The dominant model analysis of Sirt3 genetic variants is associated with susceptibility to tuberculosis in a Chinese Han population.

Molecular genetics and genomics : MGG - 1 Sept 2020

Wu Tao, Jiao Lin, Bai Hao, Hu Xuejiao, Wang Minjin, Zhao Zhenzhen, Xue Hui, Ying Binwu

Abstract excerpt

Tuberculosis (TB) is a complex infectious disease caused by the pathogen Mycobacterium tuberculosis (Mtb) which has coexisted with humanity since the Neolithic. Recent research indicated that SIRT3 plays a pivotal role in promoting the antimycobacterial response of mitochondria and autophagy during Mtb infection. A case-control study comprised 900 TB patients and 1534 healthy controls who were retrospectively...

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PMID: 32462533
DOI: 10.1007/s00438-020-01685-7

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