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Article

NAT2 Slow Acetylator Phenotype as a Significant Risk Factor for Hepatotoxicity Caused by Antituberculosis Drugs: Results From a Multiethnic Nested Case-Control Study.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 1 Aug 2025

Cheli Stefania, Torre Alessandro, Schiuma Marco, Montrasio Cristina, Civati Aurora, Galimberti Miriam, Battini Vera, Mariani Ilaria, Mosini Giulia, Carnovale Carla, Radice Sonia, Clementi Emilio, Gori Andrea, Antinori Spinello

Abstract excerpt

BACKGROUND: Under standard therapies, the incidence of drug-induced liver injury (DILI) in patients with tuberculosis ranges from 2% to 28%. Numerous studies have identified the risk factors for antituberculosis DILI; however, none have been conducted in a multiethnic real-world setting. The primary outcome of the current study was to identify the risk factors that could be used as the best predictors of DILI in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 39727196
DOI: 10.1093/cid/ciae583

Genes

NAT2

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NAT2 Slow Acetylator Phenotype as a Significant Risk Factor for Hepatotoxicity Caused by Antituberculosis Drugs: Results From a Multiethnic Nested Case-Control Study.PMID 39727196Read ↗

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