Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Influence of interleukin-4 gene polymorphisms and interleukin-4 serum level on susceptibility and severity of rheumatoid arthritis in Egyptian population.

Cytokine - 1 Mar 2013

Hussein Yousri M, El-Shal Amal S, Rezk Noha A, Abdel Galil Sahar M, Alzahrani Saad S

Abstract excerpt

BACKGROUND: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease in which interleukin-4 (IL-4) plays an important role. This study aimed to investigate the influence of IL-4 variable number of tandem repeats (VNTRs) and IL-4-590 promoter polymorphisms on RA susceptibility, activ...

Topics

Alleles
Arthritis, Rheumatoid
Case-Control Studies
Egypt
Genetic Predisposition to Disease
Humans
Interleukin-4
Joints
Middle Aged
Minisatellite Repeats
Peptides, Cyclic
Polymorphism, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Promoter Regions, Genetic

Severity of Illness Index

Source

Identifiers

PMID: 23394902
DOI: 10.1016/j.cyto.2013.01.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-23394902-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Influence of interleukin-4 gene polymorphisms and interleukin-4 serum level on susceptibility and severity of rheumatoid arthritis in Egyptian population.PMID 23394902Read ↗

Association of interleukin-4 receptor gene polymorphisms with rheumatoid arthritis in Egyptian female patients.Semantic proximity Read ↗

Correlation between IL-4 gene polymorphismas well as its mRNA expressionand rheumatoid arthritis.Semantic proximity Read ↗

Genetic polymorphisms of ACE I/D, IL-1β G > A and IL-4 VNTR among Egyptian subjects with rheumatoid arthritis.Semantic proximity Read ↗

The effects of gene polymorphisms in interleukin-4 and interleukin-6 on the susceptibility of rheumatoid arthritis in a Chinese population.Semantic proximity Read ↗

Signal transducer and activator of transcription 4 (STAT4) G>T gene polymorphism in Egyptian cases with rheumatoid arthritis.Semantic proximity Read ↗

The -590 IL-4 promoter polymorphism in patients with rheumatoid arthritis.Semantic proximity Read ↗

Meta-analysis for Association of Interleukin 4 VNTR Polymorphism with Rheumatoid Arthritis Risk and Severity.Semantic proximity Read ↗

Cytotoxic T lymphocyte associated antigen-4 (CTLA-4) +49 A>G gene polymorphism in Egyptian cases with rheumatoid arthritis.Semantic proximity Read ↗

STAT4 rs7574865 G/T polymorphism is associated with rheumatoid arthritis and disease activity, but not with anti-CCP antibody levels in a Mexican population.Semantic proximity Read ↗

IL-4 polymorphisms (rs2227284, rs2243267, and rs2243270) are associated with reduced risk of rheumatoid arthritis.Semantic proximity Read ↗

The Genetic Association Between TLR-1, -2, -4, and -6 Gene Polymorphisms and Rheumatoid Arthritis Susceptibility in a Chinese Han Population.Semantic proximity Read ↗

NFKB1 promoter -94 insertion/deletion ATTG polymorphism (rs28362491) is associated with severity and disease progression of rheumatoid arthritis through interleukin-6 levels modulation in Egyptian patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.