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Article

TNF-alpha 863C > A promoter and TNFRII 196T > G exonic variationsmay be risk factors for juvenile idiopathic arthritis

Turkish journal of medical sciences - 19 Dec 2017

Batar Bahadır, Özman Sezen, Barut Kenan, Kasapçopur Özgür, Güven Mehmet

Abstract excerpt

Background/aim: Juvenile idiopathic arthritis (JIA) is a chronic complex autoimmune disease. Genetic and environmental factors increase the risk of JIA. It is accepted that alterations in immune system pathways play an important role in the pathogenesis of JIA. The aim of the study was to investigate the possible association between immune system regulatory gene polymorphisms and JIA in Turkish patients....

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Topics

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Share to Arthritis, Juvenile
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

Share to Promoter Regions, Genetic

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Share to Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 29306244
DOI: 10.3906/sag-1612-23

Genes

TNF
CCR2
CTLA4
PTPN22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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