Article
Interleukin-4 single nucleotide polymorphisms in juvenile systemic lupus erythematosus.
International journal of immunogenetics - 1 Dec 2014
Mahmoudi M, Tahghighi F, Ziaee V, Harsini S, Rezaei A, Soltani S, Sadr M, Moradinejad M H, Aghighi Y, Rezaei N
Abstract excerpt
Juvenile systemic lupus erythematosus (JSLE) is a chronic, recurrent multisystem inflammatory disease, caused by a combination of environmental events and genetic risk factors. As cytokines, including interleukin-4 (IL-4), seem to have a role in the pathogenesis of JSLE, the investigation was performed to evaluate the associations of specific single nucleotide polymorphisms (SNPs) of IL-4 and IL-4RA genes in a...
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