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Article

Gene of the month: Axl

7 Mar 2016

Abstract excerpt

The interaction between Axl receptor tyrosine kinase and its main ligand Gas6 has been implicated in the progression of a wide number of malignancies. More recently, overexpression of Axl has emerged as a key molecular determinant underlying the development of acquired resistance to targeted anticancer agents. The activation of Axl is overexpression-dependent and controls a number of hallmarks of cancer...

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Identifiers

PMID: 26951083
DOI: 10.1136/jclinpath-2016-203629

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