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An Introduction and Overview of RON Receptor Tyrosine Kinase Signaling

17 Feb 2023

Abstract excerpt

RON is a receptor tyrosine kinase (RTK) of the MET receptor family that is canonically involved in mediating growth and inflammatory signaling. RON is expressed at low levels in a variety of tissues, but its overexpression and activation have been associated with malignancies in multiple tissue types and worse patient outcomes. RON and its ligand HGFL demonstrate cross-talk with other growth receptors and,...

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PMID: 36833444
DOI: 10.3390/genes14020517

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