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Article

Ligand Activation of TAM Family Receptors-Implications for Tumor Biology and Therapeutic Response

29 Nov 2016

Abstract excerpt

The TAM family of receptors (i.e., Tyro3, Axl, and Mertk), and their ligands Growth arrest specific factor 6 (Gas6) and Protein S (Pros1) contribute to several oncogenic processes, such as cell survival, invasion, migration, chemo-resistance, and metastasis, whereby expression often correlates with poor clinical outcomes. In recent years, there has been great interest in the study of TAM receptors in cancer,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 27916840
DOI: 10.3390/cancers8120107

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