Article
The crosstalk between AXL and YAP promotes tumor progression through STAT3 activation in head and neck squamous cell carcinoma.
Cancer science - 1 Sept 2020
Li Jiayi, Shi Chaoji, Zhou Rong, Han Yong, Xu Shengming, Ma Hailong, Zhang Zhiyuan
Abstract excerpt
Receptor tyrosine kinases (RTKs) and Yes-associated protein (YAP) are critical driving factors in tumors. Currently, the regulation of RTKs in the Hippo-YAP pathway has been recognized as an important issue. However, the relationship between AXL, one of the RTKs, and YAP in head and neck squamous cell carcinoma (HNSCC) remains unknown. In this study, the crosstalk between AXL and YAP was thoroughly investigated...
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