Article

The effect of inhibition of receptor tyrosine kinase AXL on DNA damage response in ovarian cancer

2022-06-29

Abstract excerpt

<title>Abstract</title> <p>AXL is a receptor tyrosine kinase that is often overexpressed in cancers. It contributes to pathophysiology in cancer progression and therapeutic resistance, making it an emerging therapeutic target. The first-in-class AXL inhibitor bemcentinib (R428/BGB324) was approved for treatment of acute myeloid leukaemia and was also reported to show selective sensitivity towards ovarian cancers...

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Literature Corpus work: 421d6a7c-f419-5be0-8bce-4f1bfec1413e
DOI: 10.21203/rs.3.rs-1765179/v1

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